Pyrimidine, 5-bromo-4-(trifluoromethyl)-

Pyrimidine, 5-bromo-4-(trifluoromethyl)- - Names and Identifiers

Name	5-bromo-4-(trifluoromethyl)pyrimidine
Synonyms	5-Bromo-4-(trifL 5-bromo-4-trifluoromethylprimidine 5-bromo-4-(trifluoromethyl)pyrimidine 5-BROMO-4-(TRIFLUOROMETHYL)PYRIMIDINE Pyrimidine, 5-bromo-4-(trifluoromethyl)- pyrimidine, 5-bromo-4-(trifluoromethyl)-
CAS	785777-88-0
InChI	InChI=1/C5H2BrF3N2/c6-3-1-10-2-11-4(3)5(7,8)9/h1-2H

Pyrimidine, 5-bromo-4-(trifluoromethyl)- - Physico-chemical Properties

Molecular Formula	C5H2BrF3N2
Molar Mass	226.98
Density	1.821 g/cm3
Melting Point	-4--2 °C
Boling Point	43-44 °C(Press: 16 Torr)
Flash Point	75.8°C
Vapor Presure	0.43mmHg at 25°C
pKa	-2.56±0.16(Predicted)
Storage Condition	2-8°C
Refractive Index	1.471

Pyrimidine, 5-bromo-4-(trifluoromethyl)- - Risk and Safety

Risk Codes	20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	36/37 - Wear suitable protective clothing and gloves.
HS Code	29335990

Pyrimidine, 5-bromo-4-(trifluoromethyl)- - Introduction

5-bromo-4-(trifluoromethyl)pyrimidine (5-bromo-4-(trifluoromethyl)pyrimidine) is an organic compound with the formula C5H2BrF3N2.

The following is a brief description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White crystal
-Melting point: 74 ℃
-Boiling point: 236-237 ℃
-Density: 1.85g/cm³
-Solubility: Slightly soluble in water, easily soluble in organic solvents such as ethanol and dimethylformamide

Use:
- 5-bromo-4-(trifluoromethyl)pyrimidine can be used as an important intermediate in organic synthesis.
-In drug synthesis, it can be used to synthesize anti-cancer drugs.
-It can also be used as a drug synthesis intermediate in the pharmaceutical industry.

Preparation Method:
A commonly used preparation method is by the reaction of bromopyrimidine and trifluoroformate. The specific steps are as follows:
1. The bromopyrimidine and trifluoroformate are added to a suitable solvent, such as acetonitrile.
2. Under appropriate conditions, the reaction mixture is usually heated and allowed to react for several hours.
3. After the reaction is completed, the desired product is obtained by cooling and filtration.

Safety Information:
When handling this compound, you need to pay attention to the following safety information:
- 5-bromo-4-(trifluoromethyl)pyrimidine can cause eye, skin and respiratory tract irritation, please avoid direct contact.
-When operating, please wear appropriate personal protective equipment, such as laboratory gloves and protective glasses.
-Use in a well-ventilated place to avoid inhaling excessive gas or vapor.
-Avoid contact with strong oxidants and flammable materials to prevent the risk of fire and explosion.
-Before use or disposal, please consult the relevant safety data sheet and follow the corresponding safety procedures.

Last Update：2024-04-09 19:05:52